The observation that pRb is phosphorylated at S608 and/or S795 residue in the MYCN‐amplified retinoblastoma provides an important insight into how retinoblastoma develops without mutational knock‐out of the RB1 gene which has conventionally been known as the rate‐limiting step in this process 1. The gene discussed is MYCN; the disease is retinoblastoma.