We found that in vitro treated 4T1 cell line with 25 μg/mL BDM significantly reduced the MMP‐2, MMP‐9 activities and adhesion of 4T1 cells to collagen I, fibronectin, and laminin which inhibited 77.7 % tumor incidence after inoculation without any effect in viability of cell line (Fig. 3C). The gene discussed is LAMB2; the disease is neoplasm.