The expression levels of six of the miRNAs (miR-146b, miR-130b, miR-21, miR-31 and miR-34a) were higher, the expression level of miR-145 was lower, and the expression levels of 4 genes (ACVR2B, FZD2, FZD5 and SOX2) were identified in SSc skin tissues and fibroblasts and in normal skin fibroblasts and endothelial cells that were stimulated with SSc serum. Here, FZD5 is linked to systemic sclerosis.