FZD2 and systemic sclerosis: The expression levels of six of the miRNAs (miR-146b, miR-130b, miR-21, miR-31 and miR-34a) were higher, the expression level of miR-145 was lower, and the expression levels of 4 genes (ACVR2B, FZD2, FZD5 and SOX2) were identified in SSc skin tissues and fibroblasts and in normal skin fibroblasts and endothelial cells that were stimulated with SSc serum.