GRN and Familial prostate cancer: Granulin and alpha-1-microglobulin/bikunin precursor (AMBP) were also significantly associated with GS (p-value for trend = 0.011 and 0.014, respectively), whereas neither protein was significantly overexpressed in men with prostate cancer compared with men with negative biopsy (p-value = 0.90 and 0.59, respectively) (Supplemental Fig. 1).