EGFR and non-small cell lung carcinoma: The addition of bisphosphonates to EGFR-TKIs could enhance the antitumor effect of EGFR-TKIs in patients with EGFR mutant NSCLC and BM, which suggested that third generation of bisphosphonates should be recommended in patients with advanced EGFR mutant NSCLC and BM who received EGFR-TKIs as the first-line setting.