To test whether these two forms of HHL interact, we subjected mice that had undergone demyelination (DTA(+/−):Plp1/Cre(+/−)) at 3 weeks of age and their control counterparts (DTA(+/−) mice) to noise exposure that causes synaptopathy at 8 weeks of age, and analysed their auditory function 2 weeks later (Fig. 9a). This evidence concerns the gene PLP1 and Peripheral demyelination.