Compared to vehicle control, CX-5461 reduced the tumour growth of all three PDX tumours, (Fig. 8e), but the inhibition of BRCA1 or BRCA2 deficient PDX tumours (CTG-0012 and CTG-0888) was much greater than on BRCA WT PDX tumour (CTG-1019). The gene discussed is BRCA1; the disease is neoplasm.