Additionally, cirZKSCAN1 may have acted as a competitive inhibitor to retain the endogenous RNA and to regulate the expression of tumor cell proliferation and metastasis‐related genes, including the apoptotic genes RAC2, EFNA3, and caspase 3, and the cell proliferation‐related genes TGFB1, ITGB4, CXCR4, survivin, and CCND1. This evidence concerns the gene ITGB4 and neoplasm.