Our results confirmed previous reports of substantial increases in TSLP-IL expression in AD skin as compared with that in nondiseased skin,50 especially as intense expression in the plaques of parakeratosis in SC.45 This aberrant TSLP distribution was paralleled by increased and expression of Loricrin-IL in parakeratoses, indicative of accelerated keratinocyte differentiation. Here, TSLP is linked to Alzheimer disease.