However, IL33 also has been shown to provide protection during gastrointestinal infection and dextran sodium sulfate–induced colitis by vigorously enhancing Th2 immunity.9, 10, 11, 12 Collectively, these findings suggest that IL33 may be a crucial mediator of the immune response after damage or infection in epithelial tissues. The gene discussed is IL33; the disease is digestive system infectious disorder.