PTGS2 and colonic neoplasm: Similarly, Kim et al. [122] used pathogen-free female BALB/c mice to evaluate the effect of rice bran γ-oryzanol on colon tumor growth and found that rice bran γ-oryzanol could inhibit colon tumor and reduce expression of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and 5-lipoxygenase (5-LOX).