Eight of the pathways associated genes (PLCG2, AIM2, ALOX-5, HLA-DOB, HLA-F, EIF4E2, PRKCB, and CYFIP2) were further studied by quantitative real-time PCR to validate the results obtained through the meta-analysis of publicly available RA patient’s microarray data sets. This evidence concerns the gene CYFIP2 and rheumatoid arthritis.