RIGI and Rotavirus infection: Moreover, some adhesion molecules were also significantly upregulated in PIE cells after poly(I:C) stimulation including SELE, SELL, ICAM-1, and EPCAM. In addition, we also observed a significant upregulation of the dsRNA detection sensors TLR3, RIG1, and MDA5. This is in agreement with studies in HT29 cells showing that RIG1 was upregulated by rotavirus infection (22).