After 2-week infusion of drugs in PVN, the SNA and blood pressure was decreased by ICV infusion of the AT1R antagonist, Ras inhibitor, MEK inhibitor, and caspase-3 inhibitor, but we did not assess the changes in RVLM, which may also be important to the regulation of renal hypertension. The gene discussed is CASP3; the disease is renal hypertension.