LCT and Sepsis: Compared with WT (CLP) group at 24 hours after CLP, the deficiency of Vit C worsened the organs function of Gulo−/− (CLP) mice with sepsis, acting as the serum levels of AST (Figure 1(b)), ALT (Figure 1(c)), Cr (Figure 1(d)), and Lac (Figure 1(g)) were elevated, but the levels of PCO2 (Figure 1(e)) and PO2 (Figure 1(f)) were decreased (p < 0.05 or 0.01); administration of parenteral Vit C after CLP significantly improved the appellate quotas of organ function of WT mice and Gulo−/− mice (p < 0.05 or 0.01).