As shown in Figure 1(a), compared with WT (CLP) group, the deficiency of Vit C reduced the 72-hour survival rate of Gulo−/− mice (p < 0.05); administration of parenteral Vit C significantly increased the survival rate of WT and Gulo−/− mice (p < 0.01) in sepsis. This evidence concerns the gene GULOP and Sepsis.