GULOP and Sepsis: Humanity completely powerlessly synthesizes Vit C on account of the deficiency of L-gulono-γ-lactone oxidase (Gulo), which is the pivotal enzyme in the biosynthesis of Vit C; therefore we conducted studies in transgenic mice lacking Gulo 4 (Gulo−/−), to investigate the impact of parenteral Vit C on cellular immunosuppression in sepsis and sepsis-induced MODS.