CD4 and Sepsis: Figure 2(d) showed that there were no differences between WT and Gulo−/− mice on the apoptotic level of CD4+CD25+ Tregs, with or without administered parenteral Vit C with sepsis (p > 0.05). The supernatant levels of TGF-β (Figure 2(e)) and IL-10 (Figure 2(f)) were significantly increased from CD4+CD25+ Tregs which were isolated from Gulo−/− (CLP) groups after being cultured for 24 hours (p < 0.01) but significantly decreased from CD4+CD25+ Tregs which were isolated from WT and Gulo−/− mice with administration of parenteral Vit C (p < 0.05 or 0.01).