In this study, we found that TSN-mediated CHOP induction is common, because CHOP upregulation (mRNA, top panel; protein, below panel, Fig. 4A) occurred not only in A549 cells, but also in other types of NSCLC cell lines including H157, H1792, Calu-1, H1299, SW1573 and H460 following TSN treatment (Fig. 4A). This evidence concerns the gene DDIT3 and non-small cell lung carcinoma.