TRAIL exerts its pro-apoptotic effect on tumor cells through association with membrane receptors including death receptor TRAIL-R1 (DR4) and TRAIL-R2 (DR5), whereas the binding of TRAIL to decoy receptors TRAIL-R3 (DcR1), TRAIL-R4 (DcR2), or osteoprotegerin achieves the opposite effect6. The gene discussed is TNFRSF10D; the disease is neoplasm.