Gene silencing of RhebL1 inhibited SPC-induced phosphorylation of S431 in K8 in lung cancer cells including A549, H1299, H1703, and H838 lung cancer cells (Figure 2A, Supplementary Figure 1D) and reorganization of K8 in A549 lung cancer cells (Figure 2B). Here, RHEBL1 is linked to lung carcinoma.