About 90% of CMML patients carry genomic aberrations, which includes mutations in genes encoding for epigenetic regulators (TET2, ASXL1, DNMT3A, EZH2, IDH1, IDH2), spliceosome components (SRSF2, SF3B1, ZRSF2, U2AF1), transcription factors (RUNX1, NPM1, TP53) and other signaling molecules (NRAS, KRAS, CBL, JAK2, FLT3) [11]. The gene discussed is IDH2; the disease is chronic myelomonocytic leukemia.