Here, we have unveiled the frequency, clinical significance and prognostic relevance of mutations in CSF3R, SETBP1 and SRSF2 in a cohort of 10 CNL and 56 CMML patients, with the aim of providing insights into the development of effective diagnostic and prognostic tools of CNL and CMML patients in the Chinese population. Here, SETBP1 is linked to chronic neutrophilic leukemia.