CSF3R and chronic myelomonocytic leukemia: Notably, SRSF2 mutations were detected in 25% CMML patients in our study but exclusive of mutations in CSF3R. Our multivariate analysis showed SRSF2 mutation as an independent poor predictor for OS (P = 0.028) and PFS (P = 0.001), in line with previous data from Itzykson et al. and Makishima et al. [11, 23].