In CMML, none of the 4 CSF3R mutated patients were detected with SRSF2 mutations [0/14(0%) vs. 4/42(9.5%), P < 0.001]; 1 of the 3 patients with SETBP1 mutations also had SRSF2 mutations [1/14(7.1%) vs. 2/42(4.8%), P > 0.05]. Here, SRSF2 is linked to chronic myelomonocytic leukemia.