CYP21A2 and coronary artery disorder: Although there is a large number of eQTLs in the HLA region, most of these are variants with modest (r2 < 0.5) LD with the CAD-associated variants, and the only eQTL of note was with CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2) expression in whole blood (Online Table 5).