APOC3 and hypertriglyceridemia: Thus, we examined the effects of apoC-III synthesis inhibition by volanesorsen on apolipoprotein levels in 2 human intervention trials, 1 in FCS subjects (IONIS1), who lack LPL activity (2), and 1 in subjects with prominent hypertriglyceridemia (IONIS2) of varied etiology (Figure 5A) (3).