Additional adjustment for diabetes, systolic blood pressure, and current smoking did not appreciably alter these associations (Figure 1, model 2), but further adjustment for HDL-C and non–HDL-C rendered apoB-100 and apoH nonsignificant, and weakened the associations obtained for apoC-III, apoC-II, and apoE (Figure 1, model 3). This evidence concerns the gene APOC2 and diabetes mellitus.