In particular, Schepers and colleagues showed that cells positive for leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) - a known Wnt target and marker for normal intestinal stem cells [7] - not only contribute to the initial stages of adenoma growth, but also display multipotent stem cell traits as they are able to generate all of the other cell types present in colon adenomas [6]. This evidence concerns the gene LGR5 and adenoma.