STAT3 and plasma cell myeloma: Because constitutive STAT3 activation can induce specific target genes that may stimulate cell proliferation, prevent apoptosis and promote angiogenesis [52], we examined whether GAC 17:1 can suppress the expression of STAT3-regulated gene products, overexpressed in multiple myeloma cells [53], including proliferative gene product cyclin D1, COX-2, the angiogenic protein VEGF, and anti-apoptotic gene products, such as IAP, survivin, Bcl-2, and Bcl-xL.