Since it has been previously suggested that various pharmacological agents may exhibit their effects through the up-regulation of PTEN [41,42,54] or SHP-1 [55,56,57] expression, GAC 17:1 was found to simultaneously induce both PTEN and SHP-1 expression and thus can also form a basis of novel strategy to modulate STAT3 activation in cancer cells. Here, PTEN is linked to cancer.