TGFB1 and pancreatic adenocarcinoma: In addition, another report demonstrated that the inhibition of Shp2 phosphatase activity using selective inhibitors, blocks TGF-β1-stimulated EMT in lung cells, or HGF-induced EMT in pancreatic adenocarcinoma cells [15], which further confirms the requirement of Shp2 phosphatase activity for EMT in cancer cells.