The present study takes a step in this direction by exploring spatial learning and memory in two mouse models of human genetic disorders that are associated with impaired learning and hippocampal function: Prader-Willi syndrome (PW) and Beta-catenin gene mutation (which will be denoted hereafter as BC for Beta-catenin), respectively. The gene discussed is CTNNB1; the disease is Prader-Willi syndrome.