FOXP3 and autoimmune thrombocytopenic purpura: Furthermore, compared with healthy individuals, CD3+ T cells from patients with ITP have a lower rate of apoptosis and a higher clonal expansion rate, leading to abnormal cytokine secretion, including IL-2, INF-γ, and IL-10 [46], which may be responsible for the lower CD4+CD25+FoxP3+ Treg levels and function observed in patients with active disease [43,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107].