TARDBP and amyotrophic lateral sclerosis: The remaining cases of ALS are familial, and approximately half of these cases are associated with gene mutations, including at superoxide dismutase 1 (SOD1), chromosome 9 open reading frame 72 (C9ORF72), TARDBP (the gene encoding transactive response DNA-binding protein or TDP-43), and fused in sarcoma (FUS) [1].