Moreover, failure of GluA2 Q/R site-editing has recently been demonstrated in the motor neurons of patients with ALS who have the FUSP525L mutation [65], as well as in pathological tissues of patients with C9ORF72-associated ALS [66], suggesting that a subgroup of patients with familial ALS may have similar cell death cascades to those observed in most patients with sporadic ALS. The gene discussed is GRIA2; the disease is amyotrophic lateral sclerosis.