CAB39 and Insulin resistance: AMPK signalling genes that were upregulated following the F&V concentrate intervention that have known anti-inflammatory effects include: IRS2, CAB39 and SIRT1. Previously, a study found that knockdown of IRS2 expression resulted in mice developing insulin resistance due to increased inflammation [63], while another study in mice found that AMPK signalling activated by CAB39 inhibits NF-κB activation [64].