In another study, soluble E-selectin, ICAM-1, TF and vWF were shown to be significantly higher in SAP associated with acute respiratory distress syndrome; all studied endothelial markers correlated positively with APACHE III and SOFA scores, and negatively with oxygenation index (PaO2/FiO2) during the first 10 days of hospital stay due to AP [116]. The gene discussed is VWF; the disease is alkaline phosphatase measurement.