RECK and malignant glioma: Additionally, in recent years, there has been much experimental evidence that the reversion-inducing-cysteine-rich protein with kazal motifs (RECK) could reduce the metastasis and invasion of various cancer cells, including malignant glioma [27,28], through regulating matrix metalloproteinases (MMPs) [29] and associated proteins such as Cadherin families [30].