In other words, non-protective antigens have lowest frequency of predicted T CD4+ and T CD8+ epitopes, compared with protective ones.In regards to CM analysis (Figure 1c), considering the adopted variables (antigens EO versus NPE for T and B cells), the grouping outcome, which is related with data correlation, shows the same strong association above mentioned for leishmaniasis with no stratification. This evidence concerns the gene CD4 and leishmaniasis.