In addition, Platycodin-D, a triterpene saponin extracted from the root of platycodon grandiflorum, induces autophagy in both H460 and A549 NSCLC cells exhibited by up-regulation of ATG3, ATG7, Beclin-1 and LC3-II, indicating the autophagic regulation effect of Chinese medicine [179]. The gene discussed is BECN1; the disease is non-small cell lung carcinoma.