For example, pachymic acid (also called fuling, a lanostane-type triterpenoid from Poria cocos) induces G2/M cell cycle arrest in H23 and H460 NSCLC cells by increasing reactive oxygen species (ROS), activating c-Jun N-terminal kinase (JNK) and stimulating ER stress [177]. Here, MAPK8 is linked to non-small cell lung carcinoma.