Numerous alterations in genes such as KRAS, EGFR, LKB1, PTEN, PIK3CA (encoding the p110α catalytic subunit of PI3K), as well as AKT1 mutations, EGFR and PIK3CA amplification, and PTEN deletion, have been described in NSCLC, which lead to uncontrolled mTOR pathway signaling. This evidence concerns the gene PTEN and non-small cell lung carcinoma.