As we speculated, no statistically significant difference was found between RASSF1A gene promoter methylation and patient age (the P value was 0.514 for age>60 vs age≤60), AJCC pathologic tumor stage (the P value was 0.939 for stage 0-II vs stage III-IV), or gender (the P value was 0.355 for males vs females). Here, RASSF1 is linked to neoplasm.