FOXO1 and keratoconus: In total, 3 out of the 11 SNPs, crossed the pre-established threshold for association significance with KC under the assumptions of our primary model for additive inheritance (Table 1); the rs1324183, upstream of MPDZ (OR = 1.58; 95% CI, 1.10–2.24, p = 0.01), rs2721051 downstream of FOXO1 (OR = 1.72; 95% CI, 1.07–2.77, p = 0.025) and rs4954218 (OR = 1.53; 95% CI, 1.01–2.34; p = 0.047) in an intron of MAP3K19 and upstream of RAB3GAP1 gene.