CD4 and AIDS: This was most clearly seen with rilpivirine that was rarely used in patients with high baseline viral load or low CD4 cell counts; only 3% of the rilpivirine patients had a baseline viral load >100 000 HIV-RNA copies/mL, 3% had a CD4 cell count <200/μL and none of the patients receiving rilpivirine as treatment-naïve had a history of AIDS diagnosis at treatment start.