TGFB1 and Chronic colitis: Recently, it has been reported that a new PPAR-γ modulator, GED-0507-34 Levo (GED), ameliorated intestinal fibrosis in dextran sulfate sodium-induced chronic colitis in mice (DSS mice) and inhibited “in vitro” the TGF-β–induced differentiation, both of intestinal fibroblast and epithelial cells into activated ECM-producing myofibroblasts [24].