In our model of DSS-induced chronic colitis and fibrosis in mice, we showed a marked increase in α-SMA (a marker of activated myofibroblasts), collagen I-III, and fibronectin and a parallel increased expression of pro-fibrotic IL-13, TGF-β and Smad3, compared to control mice. The gene discussed is ACTA1; the disease is Chronic colitis.