These patients were relatively young and predominantly male.[16] As increased blood levels ofIL-6, IL-8, IL-17,IL-18, TNF and IFN were also found in AD patients, we hypothesized that AD people are vulnerable to osteoporosis.[4,17] Therefore, this study used the Taiwan National Health Insurance (NHI) database to determine whether AD is a risk factor for osteoporosis. This evidence concerns the gene IL18 and osteoporosis.