SERPINE1 and thrombotic disease: The increase in FVIII:C was mainly seen in a hypercoagulable state and thrombotic disease,[10–12] and the lack of AT-III and AT may lead to thrombosis.[13,14] PC and PS activity increased to inhibit the coagulation process by inactivating VIIIα and Vα.[15,16] Plasminogen will be activated to produce plasmin by tPA and uPA, which play an important role in physiological hemostasis and thrombus degradation.[17,18] The increase in tPA and uPA activity and decrease in PAI1 activity led to the decrease in plasminogen, the production of plasmin, and the decrease in antiplasmin level.