[5–7] However, to maintain the homeostasis of the blood system, over-secreted fibrins in coagulation need to be further degraded through fibrinolysis factors such as plasminogen and plasmin.[8] Previous studies reported abnormal blood coagulation status in patients with schistosomiasis japonica,[5–7] and our former studies also found increased levels of D-D, especially in patients with advanced schistosomiasis.[8] However, few studies comprehensively examined the coagulation and fibrinolysis system together in patients with schistosomiasis japonica. This evidence concerns the gene PLG and schistosomiasis.