CD274 and neoplasm: Based on current knowledge, a higher radiation dose and concurrent chemoradiotherapy may improve the survival of patients, as has been demonstrated in previous trials.[1,2] The accumulated evidence has recently shown that RT combined with immunotherapy, such as PD-1/PD-L1 blockade, could be a promising treatment strategy.[3,4] Irradiation increases tumor destruction and triggers immune infiltration into tumors.