IFNA1 and psychiatric disorder: In multivariate analysis, after adjustment for demographic and clinical predictors of PROs, which were similar to those reported previously[8–12,20–23] and included site location, history of psychiatric disorders, fatigue, cirrhosis, the use of IFN in addition to SOF + RBV was independently associated with a greater impairment in PROs during and soon after treatment discontinuation (Table 3).