This enables cell survival during stress and promotes tumor cell proliferation.13, 15, 44 ID2 is a transcriptional target of HIF1α and enhances the function of HIF1α.21, 45 Here, we found that ID2 suppressed mitochondrial ATP production (Figures 5g and h) and regulated mETC (Figures 6a–e). The gene discussed is ID2; the disease is neoplasm.