The combined analysis showed that the positive expression rate of p53 in tumor in T3 and T4 stage was higher than that in T1 and T2 stage, however, no statistically significant correlation was observed between tumor stage and p53 expression (OR=0.47, 95%CI:0.17-1.29, P=0.14)(Figure 6). This evidence concerns the gene TP53 and neoplasm.