Interesting, Lehtinen et al. reported that mean expression of HPGD mRNA was higher in normal breast tissues than in breast cancer samples including breast ductal cancer, breast lobular cancer, breast medullary cancer and others, however, that HPGD mRNA was overexpressed in a subset of clinical breast cancers—breast medullary cancer compared to normal breast tissue samples and that high HPGD mRNA expression associated with poor prognosis [17]. This evidence concerns the gene HPGD and Hereditary breast cancer.