GDF15 and colorectal carcinoma: A stepwise increased serum MIC-1 levels in patients with benign conditions (median, 603.6 pg/mL; range, 154.8-3975.8 pg/mL; P=0.0001) and CRC (median, 859.2pg/mL; range, 112.0-5178.1 pg/mL; P<0.0001) in comparison with healthy control subjects (median, 359.9 pg/mL; range, 33.9-2398.9 pg/mL) were notably observed (Figure 1A).