Using the serum level of 1000 pg/ml MIC-1 as clinical reference value, which calculated by mean value plus three times standard deviations of healthy controls and accounted for the sake of convenient usability in clinical, the sensitivity, specificity, PPV and NPV of MIC-1 were 43.8%, 96.7%, 92.8%, and 64.1%, respectively, to identify patients with CRC. The gene discussed is GDF15; the disease is colorectal carcinoma.