Using the 489 samples from healthy subjects as controls, the area under the ROC curve of MIC-1 (AUC: 0.866, 95%CI: 0.843-0.887) for CRC is higher than that of CEA (AUC: 0.728, 95%CI: 0.699-0.756; P<0.0001; Figure 2A). This evidence concerns the gene CEACAM5 and colorectal carcinoma.