Until now, MTMR14/Jumpy was reported as a muscle-specific component and its life-long deficiency in humans was implicated in centronuclear myopathy (a congenital muscle weakness where cell nuclei are abnormally located in skeletal muscle cells) that might be caused by a late-onset inflammation and metabolic dysfunction43, 44. The gene discussed is MTMR14; the disease is autosomal dominant centronuclear myopathy.