The efficient retargeting of human CD3+ T-lymphocytes towards AML blasts triggered by the bsAb-releasing device was detected via co-culture experiments with CD33+ MOLM-13 cells, and human T-cells at a low effector-to-target (E:T) cell ratio of 1:1 (Fig. 7a). This evidence concerns the gene CD33 and acute myeloid leukemia.