ASPG and acute lymphoblastic leukemia: In the last several years, there has been an increasingly intense focus on tumor metabolism as an exploitable therapeutic avenue13, 14, 15, 16, with the success of asparaginase in the treatment of acute lymphoblastic leukemia (ALL) being just one example that has achieved widespread clinical use17, 18, and with many other metabolism-based therapies under active development19, 20.