Genomic studies have shown that PAK4 may be associated with oncogenic K-Ras, which is mutated in over 90% of pancreatic tumour samples6 and in vitro cell-based assays have shown that shRNAmediated knockdown of PAK4 in a pancreatic cancer cell line reduced cell migration5. The gene discussed is PAK4; the disease is familial pancreatic carcinoma.