CMA1 and neoplasm: To determine whether an acidic pH was responsible for the chymase-mediated generation of Ang II in hypoxic tumor cells, we adjusted the pH of the conditioned medium from normoxic-cultured CNE2 and 5–8F cells to the level of hypoxic-conditioned medium by adding 1% hydrochloric acid (HCl) (Supplementary Figure S4a).