Mutations in MYH3 have been previously shown to underlie distal arthrogryposis type 2A (DA2A; Freeman-Sheldon syndrome [MIM 193700]), DA2B (Sheldon-Hall syndrome [MIM 601680]) and DA8 (AD multiple pterygium syndrome [MIM 160720])13, 21. Here, MYH3 is linked to multiple pterygium syndrome.