Consistent with outcomes from previous studies which utilised alternate mutant SOD1 mouse models of ALS8, 9, we show here that treating with CuII(atsm) potently decreases protein markers of oxidative stress in the SOD1G93A mice (Fig. 5B) and that markers of astrogliosis are also diminished (Fig. 5C,D). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis type 8.